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SKI antibody (N-Term)

SKI Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500734
  • Target See all SKI Antibodies
    SKI (SKI Proto-Oncogene (SKI))
    Binding Specificity
    • 7
    • 3
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 25
    • 20
    • 11
    • 3
    • 3
    Human
    Host
    • 22
    • 3
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SKI antibody is un-conjugated
    Application
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Ski. it will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Peptide affinity chromatography
    Immunogen
    Ski antibody was raised against a 14 amino acid peptide from near the amino terminus of human Ski.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SKI (SKI Proto-Oncogene (SKI))
    Alternative Name
    SKI (SKI Products)
    Synonyms
    SGS antibody, SKV antibody, SKI antibody, C-SKI antibody, RGD1565591 antibody, c-ski antibody, 2310012I02Rik antibody, 2610001A11Rik antibody, AA062172 antibody, AA589460 antibody, BC004088 antibody, ski antibody, skv antibody, xski antibody, id:ibd1250 antibody, SKI proto-oncogene antibody, ski sarcoma viral oncogene homolog (avian) antibody, SKI proto-oncogene L homeolog antibody, v-ski avian sarcoma viral oncogene homolog a antibody, SKI antibody, Ski antibody, ski.L antibody, skia antibody
    Background
    TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Synonyms: Proto-oncogene c-Ski, Ski oncogene, ski oncoprotein, v-ski avian sarcoma viral oncogene homolog
    Gene ID
    6497
    UniProt
    P12755
    Pathways
    Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development
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