SIGIRR antibody (C-Term)

Catalog No. ABIN500712

Product Details anti-SIGIRR Antibody

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGIRR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Specificity: This antibody detects SIGIRR / TIR8 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of mouse SIGIRR.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 to 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for SIGIRR

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR / TIR8 (SIGIRR Products)

Synonyms: TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody

Background: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family (3). Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling (4,5). However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion (4).Synonyms: Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, UNQ301/PRO342

Gene ID: 59307

UniProt: Q6IA17

Pathways: Toll-Like Receptors Cascades