CAB39 antibody (AA 201-300) (AbBy Fluor® 750)

Catalog No. ABIN5006973

Product Details anti-CAB39 Antibody (AbBy Fluor® 750)

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Binding Specificity: AA 201-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAB39 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CAB39

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Alternative Name: MO25 alpha/CAB39 (CAB39 Products)

Synonyms: CG4083 antibody, Dmel\\CG4083 antibody, Dmo25 antibody, dMo25 antibody, l(3)00274 antibody, mo25 antibody, fc06a03 antibody, zgc:86716 antibody, wu:fc06a03 antibody, MGC78903 antibody, CAB39 antibody, MO25 antibody, AA408805 antibody, AA960512 antibody, C78372 antibody, MO25alpha antibody, CG4083 gene product from transcript CG4083-RA antibody, calcium binding protein 39 antibody, calcium binding protein 39 L homeolog antibody, Cab39 protein antibody, Mo25 antibody, cab39 antibody, cab39.L antibody, CAB39 antibody, Bm1_33380 antibody, Cab39 antibody

Background:

Synonyms: CAB39, Calcium binding protein 39, CGI 66, CGI66, MO25 alpha, MO25, Mouse protein 25 alpha, Protein Mo25.

Background: Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40- kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle, however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms.

Gene ID: 51719

Pathways: AMPK Signaling