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FBXL20 antibody (N-Term)

FBXL20 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500692
  • Target See all FBXL20 Antibodies
    FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))
    Binding Specificity
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 13
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 11
    • 2
    Rabbit
    Clonality
    • 11
    • 2
    Polyclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    This FBXL20 antibody is un-conjugated
    Application
    • 8
    • 8
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects FBXL20 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    FBXL20 antibody was raised against a 18 amino acid peptide near the amino terminus of the human FBXL20.
    Isotype
    IgG
    Top Product
    Discover our top product FBXL20 Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))
    Alternative Name
    FBXL20 (FBXL20 Products)
    Synonyms
    Fbl2 antibody, Fbl20 antibody, fbl20 antibody, MGC81000 antibody, scrapper antibody, FBL2 antibody, 2610511F20Rik antibody, 4632423N09Rik antibody, AI849362 antibody, AL117906 antibody, C86145 antibody, Scr antibody, mKIAA4147 antibody, FBXL2 antibody, Fbxl2 antibody, F-box and leucine rich repeat protein 20 antibody, F-box and leucine-rich repeat protein 20 L homeolog antibody, F-box and leucine-rich repeat protein 20 antibody, F-box/LRR-repeat protein 20 antibody, putative fbxl20 antibody, F-box and leucine rich repeat protein 2 antibody, FBXL20 antibody, fbxl20.L antibody, LOAG_14232 antibody, LOC100080065 antibody, Smp_097020.1 antibody, FBXL2 antibody, Fbxl20 antibody
    Background
    Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.Synonyms: F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like, F-box/LRR-repeat protein 20, FBL2
    Gene ID
    84961
    NCBI Accession
    NP_116264
    UniProt
    Q96IG2
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