DLGAP3 antibody (C-Term)

Catalog No. ABIN500656

Product Details anti-DLGAP3 Antibody

Target: DLGAP3 (Discs, Large (Drosophila) Homolog-Associated Protein 3 (DLGAP3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLGAP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SAPAP3.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: SAPAP3 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human SAPAP3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for DLGAP3

Target: DLGAP3 (Discs, Large (Drosophila) Homolog-Associated Protein 3 (DLGAP3))

Alternative Name: DLGAP3 (DLGAP3 Products)

Synonyms: DAP3 antibody, SAPAP3 antibody, BC058433 antibody, DAP-3 antibody, Prpl8 antibody, Sapap3 antibody, Dap3 antibody, DLG associated protein 3 antibody, discs, large (Drosophila) homolog-associated protein 3 antibody, DLGAP3 antibody, Dlgap3 antibody, dlgap3 antibody

Background: SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.Synonyms: DAP-3, DAP3, Disks large-associated protein 3, PSD-95/SAP90-binding protein 3, SAP90/PSD-95-associated protein 3, SAPAP3

Gene ID: 58512

UniProt: O95886