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RSPO1 antibody (N-Term)

RSPO1 Reactivity: Human, Rat, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500638
  • Target See all RSPO1 Antibodies
    RSPO1 (R-Spondin 1 (RSPO1))
    Binding Specificity
    • 15
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 43
    • 38
    • 33
    • 15
    • 15
    • 15
    • 15
    • 15
    Human, Rat, Mouse
    Host
    • 46
    • 6
    • 1
    Rabbit
    Clonality
    • 47
    • 6
    Polyclonal
    Conjugate
    • 22
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This RSPO1 antibody is un-conjugated
    Application
    • 36
    • 15
    • 13
    • 11
    • 10
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects RSPO1. It will not cross-react with RSPO family members.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    RSPO1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human RSPO1.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    RSPO1 (R-Spondin 1 (RSPO1))
    Alternative Name
    RSPO1 (RSPO1 Products)
    Synonyms
    RGD1565558 antibody, CRISTIN3 antibody, RSPO antibody, R-spondin antibody, Rspondin antibody, wu:fj81e05 antibody, zgc:92153 antibody, R-spondin 1 antibody, Rspo1 antibody, RSPO1 antibody, LOC100049655 antibody, rspo1 antibody
    Background
    RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular b-catenin, thereby regulating functions mediated by b-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist.Synonyms: R-spondin-1, Roof plate-specific spondin-1
    Gene ID
    284654
    NCBI Accession
    NP_001033722
    UniProt
    Q2MKA7
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