MEX3D antibody (Center)

Catalog No. ABIN500616

Product Details anti-MEX3D Antibody

Target: MEX3D (Mex-3 Homolog D (MEX3D))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEX3D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Rkhd1.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: Rkhd1 antibody was raised against a 15 amino acid peptide from near the center of human Rkhd1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for MEX3D

Target: MEX3D (Mex-3 Homolog D (MEX3D))

Alternative Name: MEX3D / RKHD1 (MEX3D Products)

Synonyms: RKHD1 antibody, MEX3D antibody, rkhd1 antibody, mex3 antibody, tino antibody, rnf193 antibody, ok/sw-cl.4 antibody, MEX-3D antibody, MEX3 antibody, OK/SW-cl.4 antibody, RNF193 antibody, TINO antibody, BC059858 antibody, Rkhd1 antibody, mex-3 RNA binding family member D antibody, mex-3 RNA binding family member D L homeolog antibody, mex3 RNA binding family member D antibody, MEX3D antibody, mex3d.L antibody, mex3d antibody, Mex3d antibody

Background: Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.Synonyms: KIAA2031, RING finger and KH domain-containing protein 1, RING finger protein 193, RNA-binding protein MEX3D, RNF193, TINO

Gene ID: 399664

UniProt: Q86XN8