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RHBDD1 antibody (C-Term)

RHBDD1 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500589
  • Target See all RHBDD1 Antibodies
    RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))
    Binding Specificity
    • 2
    • 1
    C-Term
    Reactivity
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Polyclonal
    Conjugate
    • 6
    This RHBDD1 antibody is un-conjugated
    Application
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Peptide affinity chromatography
    Immunogen
    RHBDD1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human RHBDD1.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))
    Alternative Name
    RHBDD1 (RHBDD1 Products)
    Synonyms
    MGC84665 antibody, RRP4 antibody, 4930418P06Rik antibody, mRHBDD1 antibody, RGD1306477 antibody, rRHBDD1 antibody, rhomboid domain containing 1 antibody, rhomboid domain containing 1 L homeolog antibody, RHBDD1 antibody, rhbdd1.L antibody, rhbdd1 antibody, Rhbdd1 antibody
    Background
    The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.Synonyms: HSD-50, HSD50, Rhomboid domain-containing protein 1
    Gene ID
    84236
    UniProt
    Q8TEB9
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