TBKBP1 antibody (C-Term)

Catalog No. ABIN500543

Product Details anti-TBKBP1 Antibody

Target: TBKBP1 (TBK1 Binding Protein 1 (TBKBP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBKBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Prosapip2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: Prosapip2 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TBKBP1

Target: TBKBP1 (TBK1 Binding Protein 1 (TBKBP1))

Alternative Name: TBKBP1 (TBKBP1 Products)

Synonyms: TBKBP1 antibody, ProSAPiP2 antibody, SINTBAD antibody, 3110043L15Rik antibody, Prosapip2 antibody, TBK1 binding protein 1 antibody, TBKBP1 antibody, Tbkbp1 antibody

Background: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappaB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.Synonyms: KIAA0775, ProSAPiP2, Sintbad, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1

Gene ID: 9755

NCBI Accession: NP_055541

UniProt: A7MCY6

Pathways: SARS-CoV-2 Protein Interactome