PLXDC2 antibody (N-Term)

Catalog No. ABIN500515

Product Details anti-PLXDC2 Antibody

Target: PLXDC2 (Plexin Domain Containing 2 (PLXDC2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLXDC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Plxdc2 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: Plxdc2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human Plxdc2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for PLXDC2

Target: PLXDC2 (Plexin Domain Containing 2 (PLXDC2))

Alternative Name: PLXDC2 / TEM7R (PLXDC2 Products)

Synonyms: MGC79122 antibody, TEM7R antibody, 1200007L24Rik antibody, 5430431D22Rik antibody, AI646728 antibody, AU022916 antibody, AV231634 antibody, Tem7r antibody, plexin domain containing 2 antibody, plexin domain containing 2 L homeolog antibody, PLXDC2 antibody, plxdc2.L antibody, plxdc2 antibody, Plxdc2 antibody

Background: Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57 % amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.Synonyms: Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein

Gene ID: 84898

UniProt: Q6UX71