HESX Homeobox 1 antibody (AA 51-150) (AbBy Fluor® 750)

Catalog No. ABIN5004544

Product Details anti-HESX Homeobox 1 Antibody (AbBy Fluor® 750)

Target: HESX Homeobox 1 (HESX1)

Binding Specificity: AA 51-150

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HESX Homeobox 1 antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HESX1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HESX Homeobox 1

Target: HESX Homeobox 1 (HESX1)

Alternative Name: HESX1 (HESX1 Products)

Synonyms: HES-1 antibody, Rpx antibody, RGD1563858 antibody, ANF antibody, CPHD5 antibody, RPX antibody, XANF-2 antibody, Xanf antibody, Xanf-1 antibody, Xanf1 antibody, Xanf2 antibody, anf2 antibody, anf2-A antibody, rpx antibody, anf1 antibody, hesx1 antibody, xanf-1 antibody, HESX1 antibody, GANF antibody, Anf antibody, danf antibody, zanf antibody, homeobox gene expressed in ES cells antibody, HESX homeobox 1 antibody, HESX homeobox 1 S homeolog antibody, HESX homeobox 1 L homeolog antibody, Hesx1 antibody, HESX1 antibody, hesx1.S antibody, hesx1.L antibody, hesx1 antibody

Background:

Synonyms: NULL

Background: The homeobox protein, HESX1, which is also known as Rathke?s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays.