PCDH12 antibody (N-Term)

Catalog No. ABIN500453

Product Details anti-PCDH12 Antibody

Target: PCDH12 (Protocadherin 12 (PCDH12))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDH12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PCDH12. It is predicted to not cross-react with PCDH18.

Purification: Peptide affinity chromatography

Immunogen: PCDH12 antibody was raised against a 17 amino acid peptide near the amino terminus of human PCDH12.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PCDH12

Target: PCDH12 (Protocadherin 12 (PCDH12))

Alternative Name: Protocadherin-12 / PCDH12 (PCDH12 Products)

Synonyms: PCDH12 antibody, VE-cadherin-2 antibody, VECAD2 antibody, Pcdh14 antibody, VE-cad-2 antibody, protocadherin 12 antibody, PCDH12 antibody, Pcdh12 antibody

Background: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA, further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2,289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.Synonyms: VE-cad-2, VE-cadherin-2, Vascular cadherin-2, Vascular endothelial cadherin-2

Gene ID: 51294

NCBI Accession: NP_057664

UniProt: Q9NPG4

Pathways: Cellular Glucan Metabolic Process