TP53AIP1 antibody (N-Term)

Catalog No. ABIN500433

Product Details anti-TP53AIP1 Antibody

Target: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53AIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody dreacts to p53AIP1. It will detect all three isoforms.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatograpy

Immunogen: p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 4 - 8 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-TP53AIP1 antibody (ABIN500433)

Ohno, Naito, Mukai, Yabuta, Nojima: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." in: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).

Target Details for TP53AIP1

Target: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Alternative Name: TP53AIP1 (TP53AIP1 Products)

Synonyms: P53AIP1 antibody, tumor protein p53 regulated apoptosis inducing protein 1 antibody, TP53AIP1 antibody

Background: The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to existSynonyms: p53-regulated apoptosis-inducing protein 1, p53AIP1

Gene ID: 63970

UniProt: Q9HCN2