Norrie Disease (Pseudoglioma) antibody (N-Term)

Catalog No. ABIN500373

Product Details anti-Norrie Disease (Pseudoglioma) Antibody

Target: Norrie Disease (Pseudoglioma) (NDP)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Norrie Disease (Pseudoglioma) antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects NDP.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: Norrin antibody was raised against an 18 amino acid peptide from near the amino terminus of human Norrin.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Norrie Disease (Pseudoglioma)

Target: Norrie Disease (Pseudoglioma) (NDP)

Alternative Name: NDP (NDP Products)

Synonyms: EVR2 antibody, FEVR antibody, ND antibody, evr2 antibody, fevr antibody, xnorrin antibody, Ndph antibody, RGD1563968 antibody, NDP, norrin cystine knot growth factor antibody, Norrie disease (pseudoglioma) L homeolog antibody, Norrie disease (pseudoglioma) (human) antibody, NDP antibody, ndp.L antibody, Ndp antibody

Background: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.Synonyms: EVR2, Norrie disease protein, Norrin

Gene ID: 4693

NCBI Accession: NP_000257

UniProt: Q00604

Pathways: Sensory Perception of Sound