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GLDN antibody (AA 365-460) (AbBy Fluor® 750)

GLDN Reactivity: Human, Mouse, Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 750
Catalog No. ABIN5003536
  • Target See all GLDN Antibodies
    GLDN (Gliomedin (GLDN))
    Binding Specificity
    • 14
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    AA 365-460
    Reactivity
    • 35
    • 20
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLDN antibody is conjugated to AbBy Fluor® 750
    Application
    • 35
    • 17
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Gliomedin/COLM
    Isotype
    IgG
    Top Product
    Discover our top product GLDN Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GLDN (Gliomedin (GLDN))
    Alternative Name
    Gliomedin (GLDN Products)
    Synonyms
    CLOM antibody, COLM antibody, CRG-L2 antibody, CRGL2 antibody, UNC-112 antibody, Clom antibody, Colm antibody, Crgl2 antibody, Crlg2 antibody, gliomedin antibody, GLDN antibody, Gldn antibody, gldn antibody
    Background

    Synonyms: CANCER RELATED GENE LIVER 2, Cancer related gene-Liver 2, CLOM, collomin, Colm gene name, COLM, Colmedin, CRG L2, FLJ23917, Gldn gene name, UNC 112, GLDN_HUMAN.

    Background: Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system.

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