GLDN antibody (AA 365-460) (AbBy Fluor® 750)

Catalog No. ABIN5003536

Product Details anti-GLDN Antibody (AbBy Fluor® 750)

Target: GLDN (Gliomedin (GLDN))

Binding Specificity: AA 365-460

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLDN antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gliomedin/COLM

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GLDN

Target: GLDN (Gliomedin (GLDN))

Alternative Name: Gliomedin (GLDN Products)

Synonyms: CLOM antibody, COLM antibody, CRG-L2 antibody, CRGL2 antibody, UNC-112 antibody, Clom antibody, Colm antibody, Crgl2 antibody, Crlg2 antibody, gliomedin antibody, GLDN antibody, Gldn antibody, gldn antibody

Background:

Synonyms: CANCER RELATED GENE LIVER 2, Cancer related gene-Liver 2, CLOM, collomin, Colm gene name, COLM, Colmedin, CRG L2, FLJ23917, Gldn gene name, UNC 112, GLDN_HUMAN.

Background: Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system.