Neurotrypsin antibody (N-Term)

Catalog No. ABIN500334

Product Details anti-Neurotrypsin Antibody

Target: Neurotrypsin (PRSS12) (Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurotrypsin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Neurotrypsin at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: Neurotrypsin antibody was raised against a 23 amino acid peptide from near the amino terminus of human neurotrypsin.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Neurotrypsin

Target: Neurotrypsin (PRSS12) (Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12))

Alternative Name: Neurotrypsin (PRSS12 Products)

Synonyms: PRSS12 antibody, BSSP-3 antibody, BSSP3 antibody, MRT1 antibody, Bssp-3 antibody, motopsin antibody, Nt antibody, protease, serine 12 antibody, 26S proteasome regulatory SU antibody, prsS12 antibody, neurotrypsin antibody, protease, serine 12 neurotrypsin (motopsin) antibody, PRSS12 antibody, prsS12 antibody, HAN_3g451 antibody, CpipJ_CPIJ005457 antibody, CpipJ_CPIJ005852 antibody, Prss12 antibody

Background: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.Synonyms: Leydin, Motopsin, PRSS12, Serine protease 12

Gene ID: 8492

UniProt: P56730