GDAP1 antibody (AA 151-230) (AbBy Fluor® 750)
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- Target See all GDAP1 Antibodies
- GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))
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Binding Specificity
- AA 151-230
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GDAP1 antibody is conjugated to AbBy Fluor® 750
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human GDAP1
- Isotype
- IgG
- Top Product
- Discover our top product GDAP1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))
- Alternative Name
- GDAP1 (GDAP1 Products)
- Synonyms
- CMT4 antibody, CMT4A antibody, CMTRIA antibody, ganglioside induced differentiation associated protein 1 antibody, ganglioside-induced differentiation-associated-protein 1 antibody, GDAP1 antibody, Gdap1 antibody
- Background
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Synonyms: Ganglioside induced dferentiation associated protein 1, Ganglioside-induced dferentiation-associated protein 1, GDAP1, GDAP1_HUMAN.
Background: Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.
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