NRN1 antibody (Center)

Catalog No. ABIN500332

Product Details anti-NRN1 Antibody

Target: NRN1 (Neuritin 1 (NRN1))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Neuritin.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: Neuritin antibody was raised against a 20 amino acid peptide from near the center of human neuritin.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for NRN1

Target: NRN1 (Neuritin 1 (NRN1))

Alternative Name: Neuritin (NRN1 Products)

Synonyms: NRN antibody, dJ380B8.2 antibody, 0710008J23Rik antibody, Cpg15 antibody, Nrn antibody, neuritin antibody, nrn1 antibody, zgc:92828 antibody, NRN1 antibody, cpg15 antibody, nrn antibody, nrn1-a antibody, nrn1-b antibody, nrn1b antibody, neuritin 1 antibody, neuritin 1a antibody, neuritin 1 S homeolog antibody, neuritin 1 L homeolog antibody, NRN1 antibody, Nrn1 antibody, nrn1a antibody, nrn1 antibody, nrn1.S antibody, nrn1.L antibody

Background: As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.Synonyms: NRN, NRN1

Gene ID: 51299

NCBI Accession: NP_057672

UniProt: Q9NPD7