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TMC8 antibody (AA 301-400) (AbBy Fluor® 750)

TMC8 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 750
Catalog No. ABIN5002209
  • Target See all TMC8 Antibodies
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Binding Specificity
    • 14
    • 7
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reactivity
    • 42
    • 14
    • 14
    Human
    Host
    • 42
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TMC8 antibody is conjugated to AbBy Fluor® 750
    Application
    • 34
    • 20
    • 12
    • 12
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EVER2/TMC8
    Isotype
    IgG
    Top Product
    Discover our top product TMC8 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Alternative Name
    EVER2/TMC8 (TMC8 Products)
    Synonyms
    EV2 antibody, EVER2 antibody, EVIN2 antibody, Ever2 antibody, mFLJ00400 antibody, transmembrane channel like 8 antibody, transmembrane channel-like 8 antibody, transmembrane channel-like gene family 8 antibody, TMC8 antibody, Tmc8 antibody
    Background

    Synonyms: epidermodysplasia verrucormis 2, Epidermodysplasia verrucormis protein 2, EV2, EVIN2, FLJ40668, FLJ43684, MGC102701, MGC40121, TMC8, Transmembrane channel like protein 8, TMC8_HUMAN.

    Background: Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

    Gene ID
    147138
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