ELAC2 antibody (AA 88-190) (AbBy Fluor® 750)

Catalog No. ABIN5001869

Product Details anti-ELAC2 Antibody (AbBy Fluor® 750)

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Binding Specificity: AA 88-190

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAC2 antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ELAC2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ELAC2

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Alternative Name: ELAC2 (ELAC2 Products)

Synonyms: 1110017O07Rik antibody, D11Wsu80e antibody, Hpc2 antibody, ELC2 antibody, HPC2 antibody, elaC ribonuclease Z 2 antibody, ELAC2 antibody, Elac2 antibody

Background:

Synonyms: elaC homolog 2, ElaC homolog protein 2, ELC2, Heredity prostate cancer protein 2, HPC2, putative prostate cancer susceptibility protein HPC2/ELAC2, Ribonuclease Z2, RNase Z2, tRNA 3 endonuclease 2, tRNase Z long form, tRNase Z2, Zinc phosphodiesterase ELAC protein 2.

Background: ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.

Gene ID: 60528