SCARB2 antibody (Center)

Catalog No. ABIN500172

Product Details anti-SCARB2 Antibody

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCARB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SCARB2

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for SCARB2

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Alternative Name: SCARB2 (SCARB2 Products)

Synonyms: cd36l2 antibody, fi13c07 antibody, chunp6914 antibody, wu:fi13c07 antibody, SCARB2 antibody, scarb2 antibody, AMRF antibody, CD36L2 antibody, EPM4 antibody, HLGP85 antibody, LGP85 antibody, LIMP-2 antibody, LIMPII antibody, SR-BII antibody, 9330185J12Rik antibody, Cd36l2 antibody, MLGP85 antibody, LimpII antibody, scavenger receptor class B, member 2a antibody, scavenger receptor class B member 2 antibody, scavenger receptor class B, member 2 antibody, scarb2a antibody, SCARB2 antibody, scarb2 antibody, Scarb2 antibody

Background: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 - 85 kDa in SDS-PAGE.Synonyms: 85 kDa lysosomal membrane sialoglycoprotein, CD36 antigen-like 2, CD36L2, LGP85, LIMP II, LIMP2, LIMPII, Lysosome membrane protein 2, SR-BII, SRB2, Scavenger receptor class B member 2

Gene ID: 950

UniProt: Q14108