KIAA0319 antibody (AA 682-760) (AbBy Fluor® 750)

Catalog No. ABIN5001610

Product Details anti-KIAA0319 Antibody (AbBy Fluor® 750)

Target: KIAA0319

Binding Specificity: AA 682-760

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIAA0319 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYX2/KIAA0319

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KIAA0319

Target: KIAA0319

Alternative Name: DYX2/KIAA0319 (KIAA0319 Products)

Synonyms: DYLX2 antibody, DYX2 antibody, 4930451E12Rik antibody, Kiaa0319 antibody, KIAA0319 antibody, RIKEN cDNA D130043K22 gene antibody, KIAA0319 ortholog antibody, similar to mKIAA0319 protein antibody, KIAA0319 antibody, D130043K22Rik antibody, RGD1307443 antibody

Background:

Synonyms: DLX 2, DLX2, DYLX 2, DYLX2, Dyslexia susceptibility 2, Dyslexia-associated protein KIAA0319 DYX 2, DYX2, K0319_HUMAN, Kiaa0319, MGC176717.

Background: DYX2 is a 1072 amino acid single-pass transmembrane protein that contains one MANSC domain and two PKD (Polycystic Kidney Disease) domains, which are usually found in the extracellular regions of proteins and are involved in protein-protein interactions. In DYX2, it is likely that its PKD domains mediate the interaction between neurons and glial fibers during neuronal migration. When overexpressed, this plasma membrane protein colocalizes with EEA1 (early endosome antigen 1) in large intracellular vesicles, suggesting that it is endocytosed and recycled. DYX2 is highly expressed in brain cortex, cerebellum, amygdala, putamen and hippocampus. Defects in the gene encoding DYX2 may be the cause of dyslexia type 2, a relatively common disorder that is characterized by reading performance impairment in the absence of sensory or neurologic disability. There are three isoforms of DYX2 that are produced as a result of alternative splicing events