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LASS5 antibody (C-Term)

LASS5 Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500138
  • Target See all LASS5 Antibodies
    LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))
    Binding Specificity
    • 15
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 21
    • 20
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LASS5 antibody is un-conjugated
    Application
    • 24
    • 13
    • 13
    • 11
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects LASS5 C-term). It may cross-react with the highly homologous LASS6.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    LASS5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human LASS5.
    Isotype
    IgG
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    Discover our top product LASS5 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))
    Alternative Name
    LASS5 (LASS5 Products)
    Synonyms
    lass5 antibody, trh4 antibody, LASS5 antibody, Trh4 antibody, 2310081H14Rik antibody, AU045339 antibody, AW544927 antibody, Lass5 antibody, ceramide synthase 5 antibody, ceramide synthase 5 S homeolog antibody, CERS5 antibody, cers5 antibody, cers5.S antibody, Cers5 antibody
    Background
    The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis. Multiple isoforms of LASS5 are known to exist.Synonyms: LAG1 longevity assurance homolog 5, LASS5, TRAM homolog 4, TRH4, Translocating chain-associating membrane protein homolog 4
    Gene ID
    91012
    NCBI Accession
    NP_671723
    UniProt
    Q8N5B7
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