DISP2 antibody (AA 1101-1200) (AbBy Fluor® 750)

Catalog No. ABIN5001284

Product Details anti-DISP2 Antibody (AbBy Fluor® 750)

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Binding Specificity: AA 1101-1200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISP2 antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DISP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Alternative Name: DISP2 (DISP2 Products)

Synonyms: DISP2 antibody, DISPB antibody, HsT16908 antibody, AI840597 antibody, B230210L08Rik antibody, DispB antibody, mKIAA1742 antibody, dispatched RND transporter family member 2 antibody, dispatched RND tramsporter family member 2 antibody, dispatched homolog 2 (Drosophila) antibody, DISP2 antibody, Disp2 antibody

Background:

Synonyms: DISPB, HsT16908, Protein dispatched homolog 2, DISP2, KIAA1742

Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.

Gene ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signaling