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CRTAP antibody (AA 201-300) (AbBy Fluor® 750)

CRTAP Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 750
Catalog No. ABIN5000579
  • Target See all CRTAP Antibodies
    CRTAP (Cartilage Associated Protein (CRTAP))
    Binding Specificity
    • 14
    • 9
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivity
    • 41
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 41
    • 1
    Rabbit
    Clonality
    • 41
    • 1
    Polyclonal
    Conjugate
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRTAP antibody is conjugated to AbBy Fluor® 750
    Application
    • 41
    • 19
    • 12
    • 12
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CRTAP
    Isotype
    IgG
    Top Product
    Discover our top product CRTAP Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    CRTAP (Cartilage Associated Protein (CRTAP))
    Alternative Name
    CRTAP (CRTAP Products)
    Synonyms
    zgc:85621 antibody, wu:fb47h01 antibody, CASP antibody, LEPREL3 antibody, OI7 antibody, 5730529N23Rik antibody, Leprel3 antibody, RGD1565180 antibody, cartilage associated protein antibody, cartilage-associated protein antibody, crtap antibody, CRTAP antibody, LOC5574430 antibody, CpipJ_CPIJ013810 antibody, Crtap antibody
    Background

    Synonyms: Cartilage associated protein, LEPREL3, leprecan-like 3, CASP, CRTAP_HUMAN.

    Background: CRTAP is a secreted protein localizing to the extracellular space that plays a role in collagen post-translational modifications, extracellular fibril assembly and intracellular trafficking. CRTAP is widely expressed with predominant expression in articular chondrocytes. It contains a signal peptide and a tetratricopeptide-like helical domain and is essential for normal bone formation. In the endoplasmic reticulum (ER), CRTAP forms a complex with Gros1 and CyPB (cyclophilin B) and is required for the efficient 3-hydroxylation of target prolyl residues in Collagen Type I molecules, the major structural proteins of skin and bone. Mutations in the gene encoding CRTAP can lead to autosomal recessive osteogenesis imperfecta (OI) type 7 and type 2B. OI, also known as brittle bone disease, is characterized by bone fragility and susceptibility to fractures. OI type 7 is a mild form of this disorder, while OI type 2B is a neonatal lethal condition.

    Gene ID
    10491
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