COPS4 antibody (AbBy Fluor® 680)

Catalog No. ABIN5000405

Product Details anti-COPS4 Antibody (AbBy Fluor® 680)

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS4 antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COPS4

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Alternative Name: COPS4 (COPS4 Products)

Synonyms: CG8725 antibody, CH4 antibody, Cops4 antibody, Csn4 antibody, DCH4 antibody, Dch4 antibody, Dmel\\CG8725 antibody, csn4 antibody, l(2)k08018 antibody, COPS4 antibody, SGN4 antibody, DKFZp459H0324 antibody, AW208976 antibody, D5Ertd774e antibody, fc90c08 antibody, wu:fc90c08 antibody, zgc:77137 antibody, ATS4 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 14 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 8 antibody, COP14 antibody, COP9 SIGNALOSOME SUBUNIT 4 antibody, CSN4 antibody, EMB134 antibody, EMBRYO DEFECTIVE 134 antibody, FUS4 antibody, FUS8 antibody, FUSCA 4 antibody, FUSCA 8 antibody, MBD2.17 antibody, MBD2_17 antibody, COS41.8 antibody, COP9 signalosome subunit 4 antibody, COP9 signalosome complex subunit 4 antibody, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody, Proteasome component (PCI) domain protein antibody, COP9 signalosome subunit 4 L homeolog antibody, CSN4 antibody, COPS4 antibody, CpipJ_CPIJ000966 antibody, csn4 antibody, Cops4 antibody, cops4 antibody, COP8 antibody, cops4.L antibody, csn-4 antibody

Background:

Synonyms: CH4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 complex homolog subunit 4, COP9 complex S4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 signalosome complex subunit 4, COP9 signalosome subunit 4, COPS4, CSN complex subunit 4, CSN4, CSN4 SCHPO, CSN4_HUMAN, DCH4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4, MGC94896, SGN4, Signalosome subunit 4.

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene ID: 51138

Pathways: Cell Division Cycle