CHRDL2 antibody (AA 351-429) (AbBy Fluor® 750)

Catalog No. ABIN5000027

Product Details anti-CHRDL2 Antibody (AbBy Fluor® 750)

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Binding Specificity: AA 351-429

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRDL2 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CHRDL2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CHRDL2

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Alternative Name: CHRDL2 (CHRDL2 Products)

Synonyms: BNF1 antibody, CHL2 antibody, FKSG37 antibody, 1810022C01Rik antibody, Chl2 antibody, chl antibody, si:dkey-11j5.7 antibody, si:dkey-11j5.7-like antibody, chordin like 2 antibody, chordin-like 2 antibody, CHRDL2 antibody, Chrdl2 antibody, chrdl2 antibody

Background:

Synonyms: BNF1, Breast tumor novel factor 1, CHL2, chordin like 2, Chordin like protein 2 precursor, Chordin related protein 2, CRDL2_HUMAN.

Background: CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. Amember of the chordin family of proteins, it contains a signal peptide andthree CR (cysteine-rich repeat) domains. When expressed as a recombinantprotein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

Gene ID: 25884