IL21 Receptor antibody (Extracellular Domain)

Catalog No. ABIN499988

Product Details anti-IL21 Receptor Antibody

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Binding Specificity: Extracellular Domain

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL21 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IL-21 Receptor (Extracellular Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 60 kDa band can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: Interleukin-21 Receptor / IL21R (IL21R Products)

Synonyms: IL21R antibody, il-21ra.a antibody, CD360 antibody, NILR antibody, interleukin 21 receptor antibody, interleukin 21 receptor, tandem duplicate 1 antibody, IL21R antibody, il21r.1 antibody, Il21r antibody

Background: A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.Synonyms: IL-21R, IL21 receptor, NILR, Novel interleukin receptor

Gene ID: 50615

NCBI Accession: NP_068570

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling