CDKL5 antibody (AA 401-500) (AbBy Fluor® 750)

Catalog No. ABIN4999808

Product Details anti-CDKL5 Antibody (AbBy Fluor® 750)

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Binding Specificity: AA 401-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKL5 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDKL5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDKL5

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Alternative Name: CDKL5 (CDKL5 Products)

Synonyms: issx antibody, stk9 antibody, EIEE2 antibody, ISSX antibody, STK9 antibody, BC038161 antibody, Stk9 antibody, cyclin dependent kinase like 5 antibody, cyclin-dependent kinase-like 5 antibody, CDKL5 antibody, cdkl5 antibody, Cdkl5 antibody

Background:

Synonyms: Cdkl5, CDKL5_HUMAN, Cyclin dependent kinase 5 transcript, Cyclin-dependent kinase-like 5, EIEE2, ISSX, Serine/threonine kinase 9, Serine/threonine-protein kinase 9, Stk9.

Background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome.

Pathways: Regulation of Cell Size