IER3 antibody (Center)

Catalog No. ABIN499960

Product Details anti-IER3 Antibody

Target: IER3 (Immediate Early Response 3 (IER3))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IER3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to IEX1.

Purification: Affinity chromatography purified via peptide column

Immunogen: IEX1 antibody was raised against a 24 amino acid peptide near the center of human IEX1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 2 - 4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IER3

Target: IER3 (Immediate Early Response 3 (IER3))

Alternative Name: IER3 / IEX1 (IER3 Products)

Background: IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappaB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.Synonyms: DIF2, Differentiation-dependent gene 2 protein, GLY96, IEX-1, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, PRG1, Radiation-inducible immediate-early gene IEX-1

Gene ID: 8870

UniProt: P46695

Pathways: Regulation of Carbohydrate Metabolic Process