INSM1 antibody (N-Term)

Catalog No. ABIN499952

Product Details anti-INSM1 Antibody

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to IA-1.

Purification: Affinity chromatography purified via peptide column

Immunogen: IA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: INSM1 / IA1 (INSM1 Products)

Synonyms: IA-1 antibody, IA1 antibody, INSM-1 antibody, Insm1 antibody, fc13a09 antibody, wu:fc13a09 antibody, zINSM-1 antibody, zgc:63866 antibody, INSM1 antibody, ia-1 antibody, zgc:77257 antibody, INSM transcriptional repressor 1 antibody, insulinoma-associated 1 antibody, insulinoma-associated 1b antibody, insulinoma associated 1 antibody, insulinoma associated 1 L homeolog antibody, insulinoma-associated 1a antibody, INSM1 antibody, Insm1 antibody, insm1b antibody, insm1 antibody, insm1.L antibody, insm1a antibody

Background: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100 % of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.Synonyms: Insulinoma-associated protein 1, Zinc finger protein IA-1

Gene ID: 3642

NCBI Accession: NP_002187

UniProt: Q01101