HAP1 antibody (Center)

Catalog No. ABIN499942

Product Details anti-HAP1 Antibody

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to HAP1.

Purification: Affinity chromatography purified via peptide column

Immunogen: HAP1 antibody was raised against a 19 amino acid peptide from near the center of human HAP1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for HAP1

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Alternative Name: HAP1 (HAP1 Products)

Synonyms: HAP2 antibody, HIP5 antibody, HLP antibody, hHLP1 antibody, HAP1-A antibody, HAP1-B antibody, HAP-1 antibody, huntingtin associated protein 1 antibody, huntingtin-associated protein 1 antibody, HAP1 antibody, Hap1 antibody

Background: Huntington\'s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening, the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1

Gene ID: 9001

UniProt: P54257

Pathways: Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus