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GRIK4 antibody (N-Term)

GRIK4 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499930
  • Target See all GRIK4 Antibodies
    GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))
    Binding Specificity
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 18
    • 8
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 16
    • 2
    Rabbit
    Clonality
    • 17
    • 1
    Polyclonal
    Conjugate
    • 14
    • 2
    • 1
    • 1
    This GRIK4 antibody is un-conjugated
    Application
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Grik4 antibody was raised against a 14 amino acid peptide near the amino terminus of the human Grik4.
    Isotype
    IgG
    Top Product
    Discover our top product GRIK4 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))
    Alternative Name
    Glutamate Receptor KA1 / GRIK4 (GRIK4 Products)
    Synonyms
    GRIK4 antibody, ka1 antibody, eaa1 antibody, EAA1 antibody, GRIK antibody, GluK4 antibody, KA1 antibody, 6330551K01Rik antibody, GluRgamma1 antibody, KA-1 antibody, glutamate receptor, ionotropic, kainate 4 antibody, glutamate ionotropic receptor kainate type subunit 4 antibody, glutamate receptor, ionotropic, kainate 4 L homeolog antibody, grik4 antibody, GRIK4 antibody, grik4.L antibody, Grik4 antibody
    Background
    Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.Synonyms: EAA1, Excitatory amino acid receptor 1, Glutamate receptor ionotropic kainate 4
    Gene ID
    2900
    UniProt
    Q16099
    Pathways
    Synaptic Membrane
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