TMC8 antibody (Center)

Catalog No. ABIN499810

Product Details anti-TMC8 Antibody

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to EVER2.

Purification: Affinity chromatography purified via peptide column

Immunogen: EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TMC8

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Alternative Name: TMC8 (TMC8 Products)

Synonyms: EV2 antibody, EVER2 antibody, EVIN2 antibody, Ever2 antibody, mFLJ00400 antibody, transmembrane channel like 8 antibody, transmembrane channel-like 8 antibody, transmembrane channel-like gene family 8 antibody, TMC8 antibody, Tmc8 antibody

Background: Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8

Gene ID: 147138

UniProt: Q8IU68