TMC6 antibody (N-Term)

Catalog No. ABIN499806

Product Details anti-TMC6 Antibody

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to EVER1.

Purification: Affinity chromatography purified via peptide column

Immunogen: EVER1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human EVER1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Alternative Name: TMC6 / EVER1 (TMC6 Products)

Synonyms: EVER1 antibody, zgc:92610 antibody, MGC83549 antibody, ever1 antibody, EV1 antibody, EVIN1 antibody, LAK-4P antibody, D11Ertd204e antibody, transmembrane channel like 6 antibody, transmembrane channel-like 6b antibody, transmembrane channel like 6 L homeolog antibody, transmembrane channel-like gene family 6 antibody, TMC6 antibody, tmc6b antibody, tmc6.L antibody, tmc6 antibody, Tmc6 antibody

Background: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.Synonyms: EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4, Transmembrane channel-like protein 6

Gene ID: 11322

UniProt: Q7Z403