ECSIT antibody (C-Term)
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- Target See all ECSIT Antibodies
- ECSIT
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ECSIT antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.
- Purification
- Ion exchange chromatography
- Immunogen
- Human ECSIT (C-Terminus) Peptide
- Isotype
- IgG
- Top Product
- Discover our top product ECSIT Primary Antibody
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- Application Notes
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ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C.
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- Target
- ECSIT
- Alternative Name
- ECSIT (ECSIT Products)
- Synonyms
- CG10610 antibody, DmECSIT antibody, Dmel\\CG10610 antibody, dECSIT antibody, ECSIT antibody, Sitpec antibody, SITPEC antibody, CG10610 gene product from transcript CG10610-RA antibody, ECSIT signalling integrator antibody, ecsit antibody, ECSIT signalling integrator S homeolog antibody, ECSIT antibody, CpipJ_CPIJ003637 antibody, Ecsit antibody, ecsit.S antibody
- Background
- Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.Synonyms: ECSIT homolog (Drosophila), Evolutionarily conserved signaling intermediate in Toll pathway, SITPEC, Signaling intermediate in toll pathway evolutionarily conserved, mitochondrial
- Gene ID
- 51295
- NCBI Accession
- NP_057665
- UniProt
- Q9BQ95
- Pathways
- TLR Signaling, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
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