DNAL1 antibody (C-Term)

Catalog No. ABIN499752

Product Details anti-DNAL1 Antibody

Target: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts top DNAL1.

Purification: Affinity chromatography purified via peptide column

Immunogen: DNAL1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human DNAL1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for DNAL1

Target: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Alternative Name: DNAL1 (DNAL1 Products)

Synonyms: C14orf168 antibody, CILD16 antibody, 1700010H15Rik antibody, AW121714 antibody, Dnalc1 antibody, E330027P08Rik antibody, wu:fc89a04 antibody, zgc:92542 antibody, dynein axonemal light chain 1 antibody, dynein, axonemal, light chain 1 L homeolog antibody, dynein, axonemal, light chain 1 antibody, DNAL1 antibody, dnal1.L antibody, Dnal1 antibody, dnal1 antibody

Background: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.Synonyms: C14orf168, Dynein light chain 1 axonemal

Gene ID: 83544

NCBI Accession: NP_113615

UniProt: Q4LDG9