CX3CR1 antibody (Extracellular Loop)

Catalog No. ABIN499694

Product Details anti-CX3CR1 Antibody

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Binding Specificity: Extracellular Loop

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CX3CR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: CX3CR1 antibody was raised against a peptide corresponding to amino acids in an extracellular loop of human CX3CR1. The sequence is identical to that of rat CX3CR1 and differs from that of mouse CX3CR1 by one amino acid (3,4).

Purification: Affinity chromatography purified via peptide column

Immunogen: Human CX3CR1 (Extracellular Loop) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CX3CR1 antibody can be used for detection of CX3CR1 at 1/500 dilution. THP-1cell lysate can be used as positive control and an approximately 50 kDa band can bedetected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CX3CR1

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Alternative Name: CX3CR1 / GPR13 (CX3CR1 Products)

Synonyms: CCRL1 antibody, CMKBRL1 antibody, CMKDR1 antibody, GPR13 antibody, GPRV28 antibody, V28 antibody, Rbs11 antibody, C-X3-C motif chemokine receptor 1 antibody, chemokine (C-X3-C motif) receptor 1 antibody, CX3C chemokine receptor 1 antibody, CX3CR1 antibody, Cx3cr1 antibody, LOC100559882 antibody

Background: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).Synonyms: Beta chemokine receptor-like 1, C-X3-C CKR-1, CMK-BRL-1, CMKBRL1, CX3C chemokine receptor 1, Fractalkine receptor, G-protein coupled receptor 13, V28

Gene ID: 1524

UniProt: P49238

Pathways: Cellular Response to Molecule of Bacterial Origin