APIP antibody (AA 151-242) (AbBy Fluor® 680)

Catalog No. ABIN4996612

Product Details anti-APIP Antibody (AbBy Fluor® 680)

Target: APIP (APAF1 Interacting Protein (APIP))

Binding Specificity: AA 151-242

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APIP antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APIP

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APIP

Target: APIP (APAF1 Interacting Protein (APIP))

Alternative Name: Apaf1 Interacting Protein (APIP Products)

Synonyms: APIP2 antibody, CGI29 antibody, MMRP19 antibody, dJ179L10.2 antibody, hAPIP antibody, CGI-29 antibody, Mmrp19 antibody, RGD1564562 antibody, zgc:103619 antibody, APAF1 interacting protein antibody, APAF1 interacting protein S homeolog antibody, APIP antibody, Apip antibody, apip antibody, apip.S antibody

Background:

Synonyms: MTNB_HUMAN, Apaf1 Interacting Protein, APIP2, CG129, CGI 29, MMRP19, MTRu 1 P dehydratase, Probable methylthioribulose 1 phosphate dehydratase.

Background: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Gene ID: 51074

Pathways: Methionine Biosynthetic Process