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ANKRD13B antibody (AbBy Fluor® 680)

ANKRD13B Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal AbBy Fluor® 680
Catalog No. ABIN4996529
  • Target See all ANKRD13B products
    ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
    Reactivity
    • 19
    • 17
    • 17
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ANKRD13B antibody is conjugated to AbBy Fluor® 680
    Application
    • 19
    • 12
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ANKRD13B
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
    Alternative Name
    ANKRD13B (ANKRD13B Products)
    Synonyms
    zgc:113371 antibody, AW124583 antibody, B930093C12Rik antibody, RGD1564005 antibody, ankyrin repeat domain 13B antibody, ankyrin repeat domain 13B L homeolog antibody, ankyrin repeat domain 13b antibody, ANKRD13B antibody, ankrd13b antibody, ankrd13b.L antibody, Ankrd13b antibody
    Background

    Synonyms: Ankrd13b, ANKRD13Bankyrin repeat domain 13B, ankyrin repeat domain 13B, AN13B_HUMAN.

    Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD13B (ankyrin repeat domain 13B) is a 626 amino acid protein that contains two ANK repeats and three ubiquitin-interacting motif (UIM) repeats. Conserved in dog, cow, mouse and rat, ANKRD13B exists as two alternatively spliced isoforms. The gene that encodes ANKRD13B maps to human chromosome 17, which makes up over 2.5 % of the human genome, with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is recognized as a genetic determinant of early onset breast cancer. Chromosome 17 is also linked to neurofibromatosis, dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease.

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