BIRC2 antibody (C-Term)

Catalog No. ABIN499623

Product Details anti-BIRC2 Antibody

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: C-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human cIAP (C-Terminus) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: cIAP antibody can be used for the detection of c-IAP at 1 to 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BIRC2

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Alternative Name: IAP2 / BIRC2 (BIRC2 Products)

Synonyms: API1 antibody, HIAP2 antibody, Hiap-2 antibody, MIHB antibody, RNF48 antibody, c-IAP1 antibody, cIAP1 antibody, Api2 antibody, rIAP1 antibody, IAP1 antibody, ITA antibody, AW146227 antibody, Api1 antibody, Birc3 antibody, HIAP1 antibody, IAP2 antibody, MIAP1 antibody, MIAP2 antibody, MIHC antibody, cIAP2 antibody, mcIAP1 antibody, ciap-1 antibody, birc3 antibody, api1 antibody, birc2 antibody, c-iap1 antibody, ciap1 antibody, hiap-2 antibody, hiap2 antibody, mihb antibody, rnf48 antibody, baculoviral IAP repeat containing 2 antibody, baculoviral IAP repeat-containing 2 antibody, baculoviral IAP repeat containing 2 L homeolog antibody, BIRC2 antibody, Birc2 antibody, birc2 antibody, birc2.L antibody

Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspasesSynonyms: API1, Baculoviral IAP repeat-containing protein 2, C-IAP1, HIAP-2, HIAP2, IAP homolog B, Inhibitor of apoptosis protein 2, MIHB, RING finger protein 48, RNF48, TNFR2-TRAF-signaling complex protein 2, cIAP1

Gene ID: 329

NCBI Accession: NP_001157

UniProt: Q13490

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades