CDIP1 antibody (Center)

Catalog No. ABIN499607

Product Details anti-CDIP1 Antibody

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CDIP.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center of Human CDIP

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CDIP antibody can be used for detection of CDIP at 0.25 - 0.5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CDIP1

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Alternative Name: LITAF-Like Protein (CDIP1 Products)

Background: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.Synonyms: C16orf5, CDIP, Cell death-inducing protein, Transmembrane protein I1

Gene ID: 29965

NCBI Accession: NP_037531

UniProt: Q9H305