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CDCA8 antibody (N-Term)

CDCA8 Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499603
  • Target See all CDCA8 Antibodies
    CDCA8 (Cell Division Cycle Associated 8 (CDCA8))
    Binding Specificity
    • 15
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 46
    • 13
    Rabbit
    Clonality
    • 48
    • 11
    Polyclonal
    Conjugate
    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDCA8 antibody is un-conjugated
    Application
    • 29
    • 17
    • 13
    • 13
    • 13
    • 10
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to CDCA8.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    CDCA8 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CDCA8.
    Isotype
    IgG
    Top Product
    Discover our top product CDCA8 Primary Antibody
  • Application Notes
    ELISA. Western Blot: CDCA8 antibody can be used for detection of CDCA8 at 1 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    CDCA8 (Cell Division Cycle Associated 8 (CDCA8))
    Alternative Name
    CDCA8 / Borealin (CDCA8 Products)
    Synonyms
    BOR antibody, BOREALIN antibody, DasraB antibody, MESRGP antibody, Bor antibody, Borr antibody, CG4454 antibody, Dmel\\CG4454 antibody, dBor antibody, borea antibody, Dasra-B antibody, GgDasraB antibody, 4831429J16Rik antibody, AU044747 antibody, Borealin antibody, D4Ertd421e antibody, bor antibody, dasrab antibody, borealin antibody, cdca8l antibody, sb:cb373 antibody, zgc:101607 antibody, cell division cycle associated 8 antibody, borealin-related antibody, Borealin antibody, cell division cycle associated 8 L homeolog antibody, CDCA8 antibody, borr antibody, borea antibody, Cdca8 antibody, cdca8.L antibody, cdca8 antibody
    Background
    CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.Synonyms: Cell division cycle-associated protein 8, Dasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B
    Gene ID
    55143
    NCBI Accession
    NP_060571
    UniProt
    Q53HL2
    Pathways
    Cell Division Cycle, M Phase
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