CADPS antibody (N-Term)

Catalog No. ABIN499525

This Rabbit Polyclonal antibody specifically detects CADPS in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CADPS antibody (N-Term) (ABIN499525)

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CADPS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CADPS Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to CAPS1.

Purification: Affinity chromatography purified via peptide column

Immunogen: CAPS1 antibody was raised against a 21 amino acid peptide near the amino terminus of the human CAPS1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CAPS1 antibody can be used for detection of CAPS1 by Western blot at 0.25 -0.5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CADPS

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Alternative Name: CADPS

Background: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles, CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion. Numerous isoforms of CAPS1 are known to exist. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.Synonyms: CAPS, CAPS-1, CAPS1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, KIAA1121

Gene ID: 8618

NCBI Accession: NP_899631

UniProt: Q9ULU8

Pathways: Synaptic Vesicle Exocytosis