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BORA antibody (C-Term)

BORA Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499489
  • Target See all BORA Antibodies
    BORA (Protein Aurora Borealis (BORA))
    Binding Specificity
    • 15
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 41
    • 2
    • 1
    Rabbit
    Clonality
    • 44
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BORA antibody is un-conjugated
    Application
    • 23
    • 13
    • 13
    • 12
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to Bora.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Bora antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.
    Isotype
    IgG
    Top Product
    Discover our top product BORA Primary Antibody
  • Application Notes
    ELISA. Western Blot: Bora antibody can be used for detection of Bora at 1-2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    BORA (Protein Aurora Borealis (BORA))
    Alternative Name
    Protein Aurora Borealis (BORA Products)
    Synonyms
    CG6897 antibody, Dmel\\CG6897 antibody, zgc:101616 antibody, C13orf34 antibody, 6720463M24Rik antibody, AI317232 antibody, RGD1309522 antibody, c13orf34 antibody, C12H13orf34 antibody, aurora borealis antibody, bora, aurora kinase A activator antibody, protein aurora borealis antibody, bora, aurora kinase A activator S homeolog antibody, bora antibody, Tsp_06066 antibody, Bora antibody, BORA antibody, bora.S antibody
    Background
    Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.Synonyms: BORA, C13orf34, FLJ22624, HsBora
    Gene ID
    79866
    UniProt
    Q6PGQ7
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