BFAR antibody (C-Term)

Catalog No. ABIN499449

Product Details anti-BFAR Antibody

Target: BFAR (Bifunctional Apoptosis Regulator (BFAR))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BFAR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: BFAR antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BFAR.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: BFAR antibody can be used for detection of BFAR at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for BFAR

Target: BFAR (Bifunctional Apoptosis Regulator (BFAR))

Alternative Name: BFAR / RNF47 (BFAR Products)

Background: The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors (extrinsic pathway) as well as mitochondria-dependent apoptosis (intrinsic pathway). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.Synonyms: BAR, Bifunctional apoptosis regulator, RING finger protein 47

Gene ID: 51283

NCBI Accession: NP_057645

UniProt: Q9NZS9