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BCL2L13 antibody (Intermediate Domain)

BCL2L13 Reactivity: Human, Mouse, Rat WB, EIA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499433
  • Target See all BCL2L13 Antibodies
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Binding Specificity
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reactivity
    Human, Mouse, Rat
    Host
    • 17
    • 4
    Rabbit
    Clonality
    • 17
    • 4
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BCL2L13 antibody is un-conjugated
    Application
    • 13
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product BCL2L13 Primary Antibody
  • Application Notes
    ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Abstract
    BCL2L13 Products
    Synonyms
    si:ch211-238n5.7 antibody, Mil1 antibody, BCL-RAMBO antibody, Bcl2-L-13 antibody, MIL1 antibody, E430016C20Rik antibody, Mil-1 antibody, BCL2 like 13 antibody, BCL2-like 13 (apoptosis facilitator) antibody, BCL2L13 antibody, bcl2l13 antibody, Bcl2l13 antibody
    Background
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1
    Gene ID
    23786
    UniProt
    Q9BXK5
    Pathways
    Positive Regulation of Endopeptidase Activity
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