BCL2L13 antibody (Intermediate Domain)

Catalog No. ABIN499433

Product Details anti-BCL2L13 Antibody

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Binding Specificity: Intermediate Domain

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L13 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BCL2L13

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Abstract: BCL2L13 Products

Synonyms: si:ch211-238n5.7 antibody, Mil1 antibody, BCL-RAMBO antibody, Bcl2-L-13 antibody, MIL1 antibody, E430016C20Rik antibody, Mil-1 antibody, BCL2 like 13 antibody, BCL2-like 13 (apoptosis facilitator) antibody, BCL2L13 antibody, bcl2l13 antibody, Bcl2l13 antibody

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1

Gene ID: 23786

UniProt: Q9BXK5

Pathways: Positive Regulation of Endopeptidase Activity