ANTXR1 antibody (Intermediate Domain)

Catalog No. ABIN499363

Product Details anti-ANTXR1 Antibody

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Binding Specificity: Intermediate Domain

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANTXR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: ATR antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR. It will recognize all three isoforms.

Purification: Ion exchange chromatography

Immunogen: Human ATR / TEM8 (Intermediate Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ATR antibody can be used for detection of ATR at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Alternative Name: Anthrax Toxin Receptor 1 (ANTXR1 Products)

Synonyms: ANTXR1 antibody, ATR antibody, TEM8 antibody, 2310008J16Rik antibody, 2810405N18Rik antibody, Antrx1 antibody, Tem8 antibody, anthrax toxin receptor 1 antibody, ANTXR1 antibody, Antxr1 antibody

Background: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell, acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8

Gene ID: 84168

NCBI Accession: NP_444262

UniProt: Q9H6X2