ANAPC7 antibody (C-Term)

Catalog No. ABIN499303

Product Details anti-ANAPC7 Antibody

Target: ANAPC7 (Anaphase Promoting Complex Subunit 7 (ANAPC7))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: APC7 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human APC7.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: APC7 antibody can be used for detection of APC7 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for ANAPC7

Target: ANAPC7 (Anaphase Promoting Complex Subunit 7 (ANAPC7))

Alternative Name: APC7 / ANAPC7 (ANAPC7 Products)

Synonyms: DDBDRAFT_0184417 antibody, DDBDRAFT_0235159 antibody, DDB_0184417 antibody, DDB_0235159 antibody, si:ch211-127h20.1 antibody, APC7 antibody, AW545589 antibody, T7F6.26 antibody, T7F6_26 antibody, anaphase promoting complex subunit 7 antibody, anaphase promoting complex subunit 7 L homeolog antibody, tetratricopeptide repeat (TPR)-containing protein antibody, anapc7 antibody, ANAPC7 antibody, anapc7.L antibody, Anapc7 antibody, APC7 antibody

Background: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.Synonyms: Anaphase-promoting complex subunit 7, Cyclosome subunit 7

Gene ID: 51434

NCBI Accession: NP_057322

UniProt: Q4KMX6