HTR3B
Reactivity: Rat, Mouse
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Peptide ELISA: 1: 16000 (limit dilution). Western blot: 1-3 μg/mL. Approx 51 kDa band observed in Human Brain (Cerebral Cortex,Hippocampus and Amygdala) lysates (calculated MW of 50.1 kDa according toNP_006019.1). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C up to one week or (in aliquots) at -20 °C for longer.
There are 4 main groups of receptors which bind the neurotransmitter serotonin: 5HT1, 5HT2 5HT3 and 5HT4. 5HT3B receptor is subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin). This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Through interactions with these receptors, serotonin is able to exert a wide variety of physiological functions. 5HT3 receptors are cation-selective transmitter-gated ion channels. 5HT3B receptor mutations have been implicated in depression.Synonyms: 5-HT3-B, 5-HT3B, 5-hydroxytryptamine receptor 3B